Accidental Cypermethrin Inhalation Poisoning Mistaken for Organophosphate Poisoning- A Private Rural Hospital Experience

Authors

  • Ejime Ebeigbe
  • Jeremiah A Igunma
  • Samuel Osighena Adebudo
  • Adanas Sunday
  • Benjamin Nandom
  • James Osemhen Okosun
  • Blessing Olayinka Odedeyi
  • Igho-Iggue Omavwerhe

DOI:

https://doi.org/10.64321/jcr.v3i1.06

Keywords:

Pyrethroid, organophosphate-like toxidrome, Cypermethrin, Dermal cleansing, Atropine sulphate

Abstract

Nigeria is a major pesticide importer in West Africa, owing to its large agricultural practices. Pesticides are necessary for food security and economic survival, especially in a developing economy like Nigeria. A class II pyrethroid, cypermethrin is frequently and extensively used as an insecticide in Nigeria and Africa. Exposure through ingestion of contaminated food, skin contact, or inhalation can result in poisoning. The majority of its harmful consequences show up as gastrointestinal and neurological problems. Although they are uncommon, severe cases of pyrethroid poisonings can manifest as an organophosphate-like toxidrome. This presents a diagnostic dilemma.

This case concerns a 16-year-old male from a rural Community in Ovia-North East Local government, of Edo State, Nigeria, who was diagnosed with accidental cypermethrin inhalation/ poisoning when he soaked his hair with cypermethrin-containing insecticide spray in an attempt to take care of the lice on his hair. He was initially diagnosed with a suspected case of organophosphate poisoning with hallucinations and chemical pneumonitis. He made a full recovery 2 days later after mechanical ventilation, Intravenous Fluid administration and symptomatic treatment with a low-dose muscarinic antagonist, atropine sulphate.

Cypermethrin and other pyrethroid-containing insect sprays are so easily obtained over the counter, therefore, frontline and critical care staff are facing a growing diagnostic challenge. Raising awareness of the organophosphate-like toxidrome upon presentation is the goal of this case report. One of the most important aspects of cypermethrin treatment is thorough leaning of the skin. Atropine at low doses may be used if necessary.

Author Biographies

Ejime Ebeigbe

Department of Medical Microbiology and Parasitology, University of Benin Teaching Hospital, Benin City.

Jeremiah A Igunma

Department Of Paediatrics and Child health, University of Benin Teaching Hospital, Benin-City, Nigeria.

Samuel Osighena Adebudo

Department of Medical Microbiology and Parasitology, University of Benin Teaching Hospital, Benin City.

Adanas Sunday

Department Of Paediatrics and Child health, University of Benin Teaching Hospital, Benin-City, Nigeria.

Benjamin Nandom

Department Of Paediatrics and Child health, University of Benin Teaching Hospital, Benin-City, Nigeria.

James Osemhen Okosun

Department of Orthopaedics and Traumatology, University of Benin Teaching Hospital, Benin City, Nigeria.

Blessing Olayinka Odedeyi

Department of microbiology, University of Ibadan, Oyo state, Nigeria

Igho-Iggue Omavwerhe

Department of Microbiology, University of Benin, Benin City, Nigeria.

References

Oyedele OA, Adeyeye VO, Adesoji SA. Agricultural sector and economic growth in Nigeria. J Agric Econ Dev2018; 7(1): 1-12. doi: 10.5897/JAED2018.0643

Adebayo EF, Ojo TO, Oyebade BA. Contribution of agriculture to Nigeria's GDP: An empirical analysis. J Econ Sustain Dev 2020; 11(10): 1-13.

Osakwe O, Okoro E, Ojo C. Acute poisoning in Nigeria: a review of 345 cases. Niger J Clin Pract 2018; 21(5): 631-636.

Oyedeji OA, Adeyeye VO, Adesoji SA. Pesticide poisoning in Nigeria: a 5-year review. J Environ Occup Sci 2017; 6(2): 1-8.

Kumar S, Singh A, Kumar V, et al. Pyrethrin and pyrethroid insecticides: mode of action, environmental fate, and human health effects. Environ Chem Lett 2020; 18(2): 531-543. doi: 10.1007/s10311-019-00933-6

Wang X, Liu X, Chen J, et al. Clinical manifestations and diagnosis of acute pyrethroid poisoning. Eur J Emerg Med 2020; 27(3): 231-236. doi: 10.1097/MEJ.0000000000000615

Chen S, Zhang Y, Liu X, et al. Pyrethroid poisoning: a review of clinical manifestations, diagnosis, and treatment. J Med Toxicol 2020; 16(2): 147-155. doi: 10.1007/s13181-019-00743-6

World Health Organization (WHO). Cypermethrin. In: WHO Recommended Classification of Pesticides by Hazard. Geneva: WHO; 2019. p. 34-35.

Soderlund DM. Pyrethroid insecticides: mechanisms of action and resistance. In: Marrs TC, editor. Mammalian Toxicology of Insecticides. Cambridge: Royal Society of Chemistry; 2018. p. 113-134.

Bradberry SM, Cage SA, Proudfoot AT, Vale JA. Poisoning due to pyrethroids. Toxicol Rev 2018; 37(2): 65-79.

Woollen BH, Marsh JR, Laird WJ, Lesser JE. The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 1992; 22(8): 983-991.

Eadsforth CV, Baldwin ER. Human dose-excretion studies with pyrethroid insecticides. I: Deltamethrin, permethrin, and cypermethrin. Xenobiotica 1983; 13(2): 73-81.

Anadón A, Martínez-Larrañaga MR, Castellano VJ, et al. Toxicokinetics of cypermethrin in rats. Toxicol Lett 1996; 87(2-3): 139-149.

Wu Q, Liu X, Liu W, et al. Toxicokinetics and tissue distribution of cypermethrin in rats. Environ Toxicol Pharmacol 2011; 31(2): 247-253.

Soderlund DM, Clark JM, Sheets LP, Mullin LS, Piccirillo VJ, Sargent D, et al. Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 2002; 171(2-3): 3-59.

Narahashi T. Neuronal mechanisms of action of insecticides. J Toxicol Sci 2001; 26(2): 69-84.

Bradberry SM, Proudfoot AT, Vale JA. Poisoning due to pyrethroids. Toxicol Rev 2005; 24(2): 93-106.

S. Kinsler, P.E. Levi, E. Hodgson, Relative contributions of the cytochrome P450 and flavin-containing monooxygenases to the microsomal oxidation of phorate following treatment of mice with phenobarbital, hydrocortisone, acetone, and piperonyl butoxide, Pestic. Biochem. Physiol. 37 (2) (1990) 174–181.

R. Dalvi, P. Dalvi, Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats, Drug Chem. Toxicol. 14 (1–2) (1991) 219–229.

J.D. Burns, L.T. Muller, P.F. Jenkins, C.A. Gunderson, Unilateral mydriasis associated with exposure to flea spray, Arch. Ophthalmol. 120 (5) (2002) 665.

Kolmodin-Hedman, Å. Swensson, M. Akerblom, Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate), Arch. Toxicol. 50 (1) (1982) 27–33.

M.F. Wilks, M. Wilks, Pyrethroid-induced paresthesia—a central or local toxic effect? J. Toxicol.: Clin. Toxicol. 38 (2) (2000) 103–105.

K. Brandenburg, A.S. Deinard, J. DiNapoli, S.J. Englender, J. Orthoefer, D. Wagner, 1% permethrin cream rinse vs 1% lindane shampoo in treating pediculosis capitis, Am. J. Dis. Child. 140 (9) (1986) 894–896.

D.C. Kalter, J. Sperber, T. Rosen, S. Matarasso, Treatment of pediculosis pubis: clinical comparison of efficacy and tolerance of 1% lindane shampoo vs 1% permethrin creme rinse, Arch. Dermatol. 123 (10) (1987) 1315–1319.

B. Kolmodin-Hedman, M. Åkerblom, S. Flato, G. Alex, Symptoms in forestry workers handling conifer plants treated with permethrin, Bull. Environ. Contam. Toxicol. 55 (4) (1995) 487–493.

26.W. Aldridge, An assessment of the toxicological properties of pyrethroids and their neurotoxicity, Crit. Rev. Toxicol. 21 (2) (1990) 89–104.

S. Tucker, S. Flannigan, M. Smolensky, Comparison of therapeutic agents for synthetic pyrethroid exposure, Contact Dermat. 9 (4) (1983) 316.

J. Knox, S. Tucker, editors, 1982. A new cutaneous sensation caused by synthetic pyrethroids. Clinical Research; 1982: SLACK INC 6900 GROVE RD, THOROFARE, NJ 08086.

J.M. Knox, S.B. Tucker, S.A. Flannigan, Paresthesia from cutaneous exposure to a synthetic pyrethroid insecticide, Arch. Dermatol. 120 (6) (1984) 744–746.

D.E. Ray, Toxicology of pyrethrins and synthetic pyrethroids, Pestic. Toxicol. Int. Regul. (2003) 129–158.

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Published

2026-02-04

How to Cite

Ejime Ebeigbe, Jeremiah A Igunma, Samuel Osighena Adebudo, Adanas Sunday, Benjamin Nandom, James Osemhen Okosun, … Igho-Iggue Omavwerhe. (2026). Accidental Cypermethrin Inhalation Poisoning Mistaken for Organophosphate Poisoning- A Private Rural Hospital Experience. Journal of Current Research and Studies, 3(1), 41–46. https://doi.org/10.64321/jcr.v3i1.06